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KMID : 0984920120140020005
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Journal of Skin Barrier Research
2012 Volume.14 No. 2 p.5 ~ p.12
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Sensory/Cooling Agents for Skin Discomfort
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Wei Edward T.
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Abstract
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Heat abstraction from the body`s surfaces can refresh the senses, relieve discomfort, attenuate pain, and suppress inflammation. Sensory/cooling agents are molecules that can mimic these effects without a change in tissue temperatures. Menthol is a familiar sensory agent used on the aerodigestive tract and on the skin, but its limited duration of action and side-effects are well known. Icilin is an excellent cooling agent for the mucous membranes but difficult to formulate for delivery to the skin. A number of p-menthane carboxamides have been created and show promise as novel anti-pruritic drugs. Molecules that simulate the effects of heat abstraction are termed "cryosims" to help distinguish them from menthol.
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KEYWORD
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Cooling, Cold, Menthol, Icilin, Skin, Cryosim
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